I would like to propose a workshop on the application of high-throughput sequencing technologies (i.e. 454, Solexa/Illumina, ABI) to problems in zebrafish biology. There are a wide variety of new possibilities that emerge with these high throughput sequencers that could be explored both as individual projects and community efforts. For example there is the Mouse Transcriptome Project done by Massively Parallel Signature Sequencing (MPSS) (see project here) that could be replicated in zebrafish using a platform superior to the one used for the mouse project. Possible uses for TILLING or cSNP detection, etc. could be discussed. Forum would be open to participants and possibly bringing in presentations from the main, commercially available, high-throughput sequencing platforms.
Shawn Burgess
Developmental Genomics Section
Genome Technology Branch
National Human Genome Research Institute
Bldg 50, Rm. 5537, MSC 8004
50 South Dr.
National Institutes of Health
Bethesda, MD 20892
ph: 301-594-8224
Fax: 301-496-0474
burgess@mail.nih.gov
http://genome.gov/staff/burgess
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2 comments:
I think this is an excellent proposal, and Shawn should be invited to chair it.
Because few folks in the fish community are able to talk about completed projects in this field, I think it would be useful to add talks on microarray applications to this workshop. The questions one can ask are very similar (gene expression profiling). So comparisons of old vs. new will be particularly helpful to the community. I would prefer speakers who can present biological/biomedical projects in which one of these approaches has been successfully applied over those who will merely talk about the "potential" of these technologies.
-Herwig
One possibility is to get the 3 companies that have sequencing platforms to come and present both what their machines can do and how it is being used in research settings. This has a disadvantage of being a bit of an infomercial, but it could either be supplemented with other pure research talks, or other arrangements could be made to have the sales reps available for detailed discussions of the different platforms without giving them podium time.
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