Disease Models

I would like to prose a workshop on disease models that may have a focus on developmental stages later than 3 dpf. For many organs, it is not until these later stages that they more closely resemble the adult form and/or begin to function in a more adult like manner. Further, these later stages have been more difficult to study because of the limitations of morpholinos. What kind of tools are available and what tools do we need (tissue specific KO etc.)? Tilling can be useful but, as is often the case, a gene can have an early developmental role that when lost alters subsequent development at these later stages.

steve

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Steven Farber Ph.D.
Carnegie Institution of Washington
Department of Embryology
3520 San Martin Drive
Baltimore, MD 21218
farber@ciwemb.edu
http://www.ciwemb.edu/labs/farber/index.php