Zebrafish transplantation methods, advances and challenges

I propose a workshop on advances and challenges in transplantation biology in zebrafish, emphasizing transplants into adult recipients, as opposed to embryonic and blastula transplants. This could encompass a wide range of transplantation issues including hematopoietic stem cell transplantation, tumor transplantation models, immunologic issues related to MHC-matching of donors and recipients (or lack thereof), quantitation of chimerism in engrafted recipients, immune suppression of recipients with drugs and/or radiation treatment, etc. The methods published to date have shown promise, but are not optimized. Our group (in Len Zon's lab) and others have made recent advances with our transplant methods, and I believe a community discussion would facilitate improved communication to disseminate the challenges and improvements.

Jill

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Jill de Jong, M.D., Ph.D.
Division of Hematology/Oncology
Children's Hospital Boston
300 Longwood Avenue, Karp 7
Boston, MA 02115
phone: 617-919-2077
jill.dejong@childrens.harvard.edu